What happened to cotadutide development?

AstraZeneca completed several Phase II trials showing promising results for T2D, obesity, and NASH/MASH. However, the company has not announced Phase III plans, and it is unclear whether cotadutide will advance further. Portfolio prioritization and competition from more advanced dual agonists may be factors.

How does cotadutide differ from survodutide?

Both are dual GLP-1/glucagon agonists. Survodutide (by Boehringer Ingelheim/Zealand Pharma) is dosed once weekly and is more advanced in development (Phase III). Cotadutide requires daily injection and development has stalled. The GLP-1:glucagon activity ratios also differ between the molecules.

Why is daily dosing a disadvantage?

In the competitive GLP-1 agonist market, once-weekly injection is the standard for newer agents (semaglutide, tirzepatide, dulaglutide). Once-daily dosing increases injection burden and may reduce patient adherence and market competitiveness.

What is the recommended dose range for Cotadutide?

The research dose range is 100–300 mcg SC once daily (Phase 2 tested up to 300 mcg), administered via Subcutaneous, Once daily.

peptide dosing

Cotadutide Dosing & Reconstitution Guide

Complete dosing reference for Cotadutide (Metabolic / Dual GLP-1/Glucagon Agonist). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Subcutaneous Frequency: Once daily Dose Range: 100–300 mcg SC once daily (Phase 2 tested up to 300 mcg)

Safety & Contraindications

Safety: Common: nausea, vomiting, diarrhea, decreased appetite (GLP-1 class effects) GI adverse events are dose-dependent; titration helps manage tolerability Once-daily dosing may produce more GI side effects than weekly formulations due to peak-trough fluctuations

Contraindications: Personal or family history of medullary thyroid carcinoma (GLP-1 class caution); Multiple endocrine neoplasia syndrome type 2 (MEN2); Known hypersensitivity to cotadutide

Peptide Tools

Reconstitution CalculatorCalculate concentration and syringe units for any peptide vial with visual syringe guide.

Dosage & Cycle PlannerPlan a multi-week peptide cycle. Calculate total supply needed and vial counts.

Bacteriostatic Water CalculatorCalculate how many vials of bacteriostatic water you need for your peptide stack.

Cost-Per-Milligram CalculatorCompare vendors side-by-side. Find the best value per milligram and per dose.

Frequently Asked Questions

Related Resources

Browse All Research Peptides

Explore More

Cotadutide Dosing Guide Peptides for Metabolic Health Peptides for Weight Management

Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.