Can AICAR replace exercise?

AICAR activates many of the same metabolic pathways as exercise, but it cannot replicate the full spectrum of exercise benefits (mechanical loading, cardiovascular conditioning, neuromotor coordination, bone density). It may provide some metabolic benefits for those unable to exercise but is not a complete substitute.

Why is AICAR banned in sports?

WADA banned AICAR in 2009 because it provides exercise-mimetic benefits (enhanced endurance, fat oxidation, glucose utilization) without requiring actual training. It was classified as a metabolic modulator.

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is an AMP-kinase activator researched as an exercise mimetic, promoting fat oxidation and metabolic adaptation without physical activity.

What is the recommended dose range for AICAR?

The research dose range is 1000-5000 mcg per injection, administered via Subcutaneous injection, Once daily.

peptide dosing

AICAR Dosing & Reconstitution Guide

Complete dosing reference for AICAR (Metabolic / Exercise Mimetic). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Subcutaneous injection Frequency: Once daily Dose Range: 1000-5000 mcg per injection Cycle Length: 8-12 weeks on, 4-8 weeks off Timing: Morning or pre-exercise (30-60 minutes before)

Reconstitution

Vial Size: 50mg Water Volume: 3mL Concentration: 16.7mg/mL

Titration Schedule

Weeks 1-2: 1000 mcg once daily Weeks 3-4: 2000 mcg once daily Weeks 5-8: 3000 mcg once daily Weeks 9+ (advanced): 4000-5000 mcg once daily

Storage

Lyophilized: Room temperature, protect from moisture, up to 24 months Reconstituted: Refrigerate 2-8 °C, use within 21 days

Injection Sites

Abdomen, Outer thigh

Safety & Contraindications

Safety: In clinical trials (IV acadesine): transient hyperuricemia, mild hypoglycemia at higher doses Injection site reactions with SC administration Theoretical risk of lactic acidosis with excessive AMPK activation

Contraindications: Hypoglycemia or diabetes on insulin/sulfonylureas (additive glucose-lowering); Severe hepatic impairment; Gout or hyperuricemia (AICAR elevates uric acid)

Peptide Tools

Reconstitution CalculatorCalculate concentration and syringe units for any peptide vial with visual syringe guide.

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.