Why was Adipotide development stopped?

Despite dramatic fat loss in monkeys (11% body weight in 4 weeks), adipotide caused reversible but significant kidney damage because prohibitin is also expressed in renal proximal tubule cells. The therapeutic window was too narrow for safe clinical use.

Is Adipotide available for purchase?

Some grey-market research peptide vendors sell products labeled as Adipotide/FTPP. The identity, purity, and safety of these products is entirely unverified. Given the known kidney toxicity, self-administration carries serious risk.

Could Adipotide be reformulated to avoid kidney damage?

Researchers have explored modifying the targeting domain to increase adipose selectivity and reduce prohibitin binding in kidney tissue, but no successful reformulation has been published. The fundamental challenge is that prohibitin expression in the kidney is a biological fact that cannot be easily circumvented by peptide engineering alone. The approach of vascular-targeted adipose destruction has been largely superseded by GLP-1 agonists and other safer anti-obesity therapeutics.

What is the recommended dose range for Adipotide?

The research dose range is 250-1000 mcg per injection (EXPERIMENTAL — NO ESTABLISHED HUMAN DOSE), administered via Subcutaneous injection, Once daily.

peptide dosing

Adipotide Dosing & Reconstitution Guide

Complete dosing reference for Adipotide (Experimental Fat Loss). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Subcutaneous injection Frequency: Once daily Dose Range: 250-1000 mcg per injection (EXPERIMENTAL — NO ESTABLISHED HUMAN DOSE) Cycle Length: 4-8 weeks maximum (based on primate protocol) Timing: Morning

Titration Schedule

Weeks 1-2: 250 mcg once daily Weeks 3-4: 500 mcg once daily Weeks 5-8: 750 mcg once daily Weeks 9+ (max): 1000 mcg once daily

Storage

Lyophilized: Refrigerate or freeze, protect from light Reconstituted: Refrigerate 2-8 °C, use within 14 days

Injection Sites

Abdomen

Safety & Contraindications

Safety: CRITICAL: Reversible kidney toxicity observed in all primate studies Mechanism: prohibitin expression in kidney proximal tubule cells causes off-target damage Elevated BUN and creatinine during treatment; reversed after discontinuation

Contraindications: Any renal impairment; Dehydration or conditions predisposing to acute kidney injury; No human use is recommended — this is an experimental research compound

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.