ACE-031 Dosing & Reconstitution Guide
Dosing Protocol
Route: Subcutaneous injection (DISCONTINUED CLINICAL PROGRAM) Frequency: Once every 2 weeks (from clinical trial protocol) Dose Range: 0.5-3 mg/kg every 2 weeks (clinical trial doses) Cycle Length: Clinical trials ran 12-24 weeks Timing: Any time of day
Titration Schedule
Clinical protocol: 1-3 mg/kg SC every 14 days
Storage
Lyophilized: Freeze at -20 °C or below Reconstituted: Refrigerate 2-8 °C, use within 24 hours
Injection Sites
Abdomen, Thigh
Safety & Contraindications
Safety: CRITICAL: Vascular safety signals led to clinical discontinuation Epistaxis (nosebleeds) in multiple subjects Telangiectasias (dilated blood vessels in skin/mucosa)
Contraindications: History of hereditary hemorrhagic telangiectasia (HHT); Bleeding disorders; Vascular malformations