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Kisspeptin vs Oxytocin

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

Kisspeptin: COxytocin: A
AttributeKisspeptinOxytocin
CategoryReproductive / HormonalReproductive / Hormonal
Evidence RatingC — Phase I–II Clinical TrialsA — Approved Medication with Strong Human Data
Clinical StatusInvestigational / Active clinical trials in reproductive medicineFDA-approved (Pitocin for labor induction, augmentation of labor, and postpartum hemorrhage)
MechanismKisspeptin binds to GPR54 (KISS1R) on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This drives LH and FSH secretion from the pituitary, which increases endogenous testosterone/estrogen production. Kisspeptin works through the natural HPG axis cascade without suppressing it (u...Oxytocin binds to the oxytocin receptor (OXTR), a Gq/11-coupled GPCR expressed in uterine myometrium, mammary tissue, and the central nervous system. Receptor activation triggers phospholipase C-mediated hydrolysis of PIP2 to IP3 and DAG, causing intracellular calcium release from the sarcoplasmic r...
Half-LifeKisspeptin-54: ~28 minutes IV; KP-10: ~4 minutes~1-6 minutes (IV)
Bioavailability—~2-5% intranasal
Molecular WeightKisspeptin-54: ~5862 g/mol; KP-10: ~1302 g/mol~1007.2 g/mol
WADA StatusNot ListedNot Listed
Research Half-LifeKisspeptin-54: ~28 minutes IV; KP-10: ~4 minutes~1-6 minutes (IV)
Key Use Cases
  • Reproductive Health
  • Reproductive Health
Safety Concerns
  • Generally well-tolerated in clinical trials at studied doses
  • Short-acting -- effects are transient
  • Continuous administration may cause desensitization/tachyphylaxis of the reproductive axis
  • Uterine hyperstimulation/tachysystole: can cause excessive contractions leading to fetal distress; requires continuous fetal monitoring
  • Water intoxication and hyponatremia: oxytocin has antidiuretic properties at high doses; risk increases with prolonged infusion and hypotonic IV fluids
  • Uterine rupture: rare but life-threatening, especially in patients with prior uterine surgery
Contraindications
  • Pregnancy (potential to disrupt hormonal balance)
  • Hormone-sensitive cancers (breast, prostate, ovarian)
  • Conditions where gonadotropin stimulation is contraindicated
  • Central precocious puberty (kisspeptin system already overactive)
  • Significant cephalopelvic disproportion or unfavorable fetal position
  • Placenta previa or vasa previa
  • Prior classical (vertical) cesarean section or major uterine surgery
  • Active genital herpes infection
Regulatory (US)Not FDA-approved. Investigational use in clinical trials. WADA-prohibited.FDA-approved (Pitocin). Used for labor induction, augmentation, and postpartum hemorrhage management.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationKisspeptinOxytocin
Purity Standard>99%>99%
CAS Number374675-21-550-56-6
Molecular FormulaC₆₃H₈₃N₁₇O₁₄C₄₃H₆₆N₁₂O₁₂S₂
Available Formats10mg10mg
Batch COAs Published——
Stock StatusOut of stockOut of stock

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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