small molecules

5-Amino-1MQ: NNMT Inhibition and the NAD+ Salvage Pathway

5-Amino-1MQ is not a peptide. It is a small-molecule quinolinium salt that inhibits nicotinamide N-methyltransferase (NNMT). Its chemical identity, the methyl-transfer reaction it blocks, how that reaction sits beside the NAD+ salvage pathway, and how thin the compound-specific literature is.