gpcr signalling

Sermorelin: GHRH(1-29) Structure and Receptor Signalling in Pituitary Cells

Sermorelin is the first 29 residues of the 44-residue growth hormone-releasing hormone, amidated at the C-terminus, and a full agonist at the GHRH receptor. How the receptor couples to Gs, how cyclic AMP and protein kinase A lead to calcium entry, and how calcium drives exocytosis in pituitary cells.