cyclic-peptides
3 articles tagged with ‘cyclic-peptides’
DNA-Encoded Libraries Enable Tunable Cyclic Peptide Discovery
Researchers led by Petrov et al. in Nature Communications developed a dual-display ESAC library that provides three levels of conformational restraint in cyclic peptides: open, semi-closed, and fully closed. This 56 million-member library addresses purity and diversity issues in conventional DNA-encoded libraries. Selections against thrombin, streptavidin, and PLAP revealed target-specific preferences for peptide flexibility, guiding future designs.
Cyclo-zp80r Boosts NFC Orange Juice Preservation
A study in Foods shows the cyclic peptide cyclo-zp80r effectively combats Salmonella enterica and Listeria monocytogenes in NFC orange juice, reducing S. enterica counts by 3.6 Log CFU/mL in one day. It outperforms nisin, raises Galleria mellonella larvae survival from 0% to 40%, and remains stable at 121°C. Mechanisms include membrane disruption, ROS production, and DNA binding, though production faces purification challenges.
Peptide Library Design: Synthesis, Types, and Screening
Synthetic peptide libraries consist of small peptides made through chemical synthesis, with sizes calculated as 20^n using natural amino acids. Cyclic and linear variants support drug discovery, enzyme inhibition, and vaccine development. Screening methods like phage display and ELISA identify high-affinity binders from these libraries.