Nootropic / Neuroprotective Research Peptides Guide
In-depth research guide covering 6 peptides in the Nootropic / Neuroprotective category. Includes evidence ratings, mechanisms, and clinical status for each compound.
Overview
This guide covers 6 research peptides in the Nootropic / Neuroprotective category. Each compound is evaluated on its evidence base, mechanism, safety profile, and current clinical status.
Semax — Preclinical
Evidence: D | Status: Approved in Russia and Ukraine for stroke and cognitive disorders; not approved elsewhere
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from adrenocorticotropic hormone (ACTH) fragment 4-10, with an added Pro-Gly-Pro sequence for metabolic stability. Molecular weight is approximately 813.
Use cases: Cognitive Enhancement
Cerebrolysin — Phase I–II Clinical Trials
Evidence: C | Status: Approved as prescription drug in 50+ countries (Austria, Russia, China, South Korea, and others). Not FDA-approved. Over 150 clinical trials with >7,000 patients.
Cerebrolysin is a brain-derived peptide complex consisting of low-molecular-weight neuropeptides (25%) and free amino acids (75%), produced by enzymatic hydrolysis of purified porcine brain proteins.
Use cases: Cognitive Enhancement
Pinealon — Preclinical / Uncontrolled Russian Studies
Evidence: D | Status: Preclinical / small open-label Russian studies only. No controlled clinical trials. Sold as a dietary supplement in Russia.
Pinealon (Glu-Asp-Arg, EDR) is a synthetic tripeptide (MW ~418 g/mol) developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology as a bioregulatory peptide targeting brain and pineal gland function.
Use cases: Neuroprotection Research, Anti-Aging Research
Cortagen — Preclinical / Uncontrolled Russian Studies
Evidence: D | Status: Preclinical / small open-label Russian studies only. No controlled clinical trials. Available as a dietary supplement in Russia.
Cortagen (Ala-Glu-Asp-Leu, AEDL) is a synthetic tetrapeptide (MW ~446 g/mol) developed by Vladimir Khavinson as a bioregulatory peptide targeting the cerebral cortex.
Use cases: Neuroprotection Research, Anti-Aging Research
N-Acetyl Semax Amidate — No Clinical Data
Evidence: D | Status: Research chemical only. No published clinical trials. No regulatory evaluation. All pharmacological claims are extrapolated from Semax data.
N-Acetyl Semax Amidate (NASA) is a modified derivative of Semax, a synthetic analog of ACTH(4-10) developed in Russia. The N-acetyl and C-amide modifications are intended to enhance metabolic stability and membrane permeability compared to the...
Use cases: Research Chemical, Nootropic Research
PE-22-28 — Preclinical Only
Evidence: D | Status: Preclinical tool compound only. No clinical trials. No regulatory evaluation.
PE-22-28 is a 7-amino-acid peptide derived from a truncation of spadin, a natural peptide fragment of the sortilin propeptide. It acts as an antagonist of the TREK-1 potassium channel (TWIK-related K+ channel 1), which has been implicated as an...
Use cases: Antidepressant Research, Ion Channel Research
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Quality Documentation
Review batch documentation before making research purchasing decisions. Volta pairs product education with COA literacy so researchers can evaluate purity, identity, lot details, and testing context.
Product cards on this page link to current catalog entries and available quality documentation.
Related Research News
FDA Panel Recommends Semax for Pharmacy Compounding: Manufacturing News
An FDA advisory panel has recommended the peptide Semax be added to the pharmacy compounding list, a move that could expand access for researchers. The decision comes amid broader discussions about peptide regulation, including a vote against emideltide. This semax manufacturing news highlights shifting industry dynamics.
Semax Research: Mechanisms of Neuroprotection, Memory, and Vascular Recovery in Preclinical Models
Explore research on Semax: memory, neuroprotection, cerebral ischemia, gene expression, and calcium homeostasis in preclinical studies.
Boost Focus and Clarity with Selank and Semax Duo
Selank and Semax, synthetic peptides from Russian research labs, offer complementary cognitive benefits. Selank reduces anxiety and sharpens attention by balancing neurotransmitters and upregulating BDNF. Semax sustains focus through neuroprotection and neurotrophin enhancement, with studies showing improved memory under stress when used together.
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