Peptides for Sleep
Overview
5 research peptides are currently studied for sleep. This guide ranks them by evidence strength and covers their mechanisms, safety profiles, and current clinical status.
Sermorelin — Phase I–II Clinical Trials
Evidence Rating: C Category: Growth Hormone Secretagogue
Sermorelin is a synthetic 29-amino-acid peptide (MW ~3357.9 g/mol) corresponding to the first 29 amino acids of naturally occurring growth hormone-releasing hormone (GHRH). It was previously FDA-approved as Geref for the diagnosis and treatment of growth hormone deficiency in children, though the pr...
Key claims: Stimulates endogenous growth hormone release; Improves body composition in adults.
MK-677 — Phase I–II Clinical Trials
Evidence Rating: C Category: Growth Hormone Secretagogue
MK-677 (Ibutamoren) is a potent, long-acting, orally-active, non-peptide ghrelin receptor (GHS-R1a) agonist that stimulates growth hormone release without injections. Unlike injectable GH peptides such as GHRP-6 or Ipamorelin, MK-677 can be taken orally and maintains elevated GH and IGF-1 levels for...
Key claims: Increases growth hormone and IGF-1 levels; Improves sleep quality.
N-Acetyl Selank Amidate — Early Human / Mixed Evidence
Evidence Rating: C Category: Nootropic / Anxiolytic
N-Acetyl Selank Amidate is a modified version of Selank with N-acetylation and C-amidation for increased metabolic stability. Base Selank is approved in Russia for anxiety and cognitive disorders. This modified form is popular for intranasal use in the research peptide community.
Key claims: Anxiety reduction; Longer duration vs standard Selank.
Ipamorelin — Preclinical
Evidence Rating: D Category: Growth Hormone Secretagogue
Ipamorelin is the most selective growth hormone secretagogue (GHS) available, a synthetic pentapeptide (MW ~711.86 g/mol, formula C38H49N9O5) that stimulates pulsatile GH release from the pituitary gland without significantly affecting cortisol, prolactin, or appetite. It is widely regarded as the m...
Key claims: Increases growth hormone levels; Improves body composition.
DSIP — Preclinical
Evidence Rating: D Category: Sleep / Neuropeptide
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, C35H48N10O15) first isolated from rabbit brain in 1977 by Schoenenberger and Monnier. Named for inducing delta (slow-wave) EEG patterns in animals, it interacts with multiple neuroendocrine...
Key claims: Promotes delta/slow-wave sleep; Reduces cortisol and stress.
Related Products
Related Research News
Synergistic Growth Hormone Effects of Sermorelin and Ipamorelin Blend
Research peptides Sermorelin and Ipamorelin may work together to boost growth hormone release from pituitary cells through distinct pathways. Sermorelin mimics the active part of natural GHRH, while Ipamorelin targets GHS-R1a receptors selectively. Laboratory studies indicate this combination could produce higher hGH peaks than either alone, with potential anabolic benefits via IGF-1.
Sermorelin Effects on Pituitary and Testicular Cells
Sermorelin, a 29-amino-acid analog of growth hormone-releasing hormone, activates receptors on anterior pituitary cells to boost hGH secretion roughly twofold, from 1.1 to 2.2 μg/L over 12 hours. Studies show this leads to IGF-1 increases of 27-28% and may enhance testosterone production in Leydig cells via upregulated IGF-1. Lab experiments highlight cAMP-PKA signaling and calcium-dependent mechanisms driving these responses.
CJC-1295 with DAC and Ipamorelin: Growth Hormone Research Guide
CJC-1295 with DAC and Ipamorelin represent key compounds in growth hormone research, targeting distinct pathways for GH and IGF-1 signaling. CJC-1295 with DAC acts as a long-acting GHRH analogue with a half-life of 5.8 to 8.1 days, while Ipamorelin functions as a selective growth hormone secretagogue via the ghrelin receptor. Together, they support studies on metabolism, recovery, and body composition.