GHK-Cu 50mg (Copper Peptide)

GHK-Cu, Copper Peptide, is a naturally occurring human tri-peptide. In plasma, the level of GHK-Cu is about 200 ng/ml at age 20. By the age of 60, the level drops to 80 ng/ml. Scientific studies conducted in different research laboratories around the world have established that human tri-peptide GHK-Cu possesses a plethora of biological actions including activation of wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth. Recent studies indicate its important role in stem cell biology and anti-tumor defense. Since GHK-Cu plays an important role in skin biology, it is widely used in cosmetics as a reparative and anti-aging ingredient.

A 2% GHK gel showed promising results in treatment of 120 diabetic patients, increasing the percentage of ulcer closure from 60.8% to 98.5%, and decreasing the percentage of infection from 34% to 7%.

Copper peptide GHK-Cu is widely used in anti-aging cosmetics (INCI name: Copper tripeptide-1). Several controlled facial studies confirmed anti-aging, firming and anti-wrinkle activity of copper peptide GHK-Cu. Abdulghani et al. established that facial cream containing GHK-Cu increased collagen in photoaged skin of 20 female volunteers, performing better than vitamin C and retinoic acid. Leyden et al. conducted 12 weeks facial study of GHK-Cu containing face and eye cream, reporting significant improvement of skin laxity, clarity and appearance, reduced fine lines and the depths of wrinkles and increased skin density and thickness comparing to placebo. GHK-Cu eye cream performed better than vitamin K cream. Finkley et al. conducted 12 week facial study on 67 women and reported that GHK-Cu cream applied twice daily improved aged skin appearance, increased thickness, reduced wrinkles and strongly stimulated dermal keratinocyte proliferation as determined by histological analysis of biopsies. The same study found copper peptide GHK-Cu to be non-toxic and non-irritating.

Copper peptide GHK-Cu and its analogues were found to strongly stimulate hair growth. The efficiency of synthetic analog of GHK-Cu was similar to that of 5% minoxidil.

Recent studies have revealed many new aspects of molecular actions of the copper-peptide GHK-Cu. Pollard et al established that GHK-Cu is able to restore function of human fibroblasts damaged by radiation treatment thus accelerating the healing and regenerative processes.

In 2005, Ahmed et al. demonstrated that GHK promotes nerve regeneration. Axon regeneration was studied using collagen tubes with incorporated peptides. GHK increased the production of nerve growth factors, expression of integrins and increased the rate of regeneration of myelinated nerve fibers.

In 2009, a group of researchers from Seoul National University demonstrated that the copper-peptide GHK-Cu stimulated proliferation of keratinocytes and increased expression of integrins and p63 protein in the epidermal stem cells. Since p63 is considered to be an important marker of stem cell and anti-senescence protein, the authors concluded that GHK-copper is able to revive the proliferative potential of epidermal stem cells and increase their ability to repair tissue.

In 2010, Hong Y. et al. demonstrated that GHK-Cu is able to reverse the expression of certain genes involved in metastatic spreading of colon cancer. GHK-Cu was effective at a very low concentration.