All Comparisons
IGF-1 vs MGF
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
IGF-1: AMGF: D
| Attribute | IGF-1 | MGF |
|---|---|---|
| Category | Growth Factor | Growth Factor |
| Evidence Rating | A — FDA Approved | D — Preclinical |
| Clinical Status | FDA-approved (Increlex/mecasermin) for severe primary IGF-1 deficiency. | Preclinical only. No human clinical trials. |
| Mechanism | IGF-1 binds to the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase that activates the PI3K/Akt pathway (promoting cell survival and protein synthesis) and the MAPK/ERK pathway (promoting cell proliferation). In circulation, 95-99% of IGF-1 is bound to IGF binding proteins, primarily IGFBP-3 in a... | MGF is expressed as part of the IGF-1 gene through alternative splicing in response to mechanical overload or tissue damage. The E-domain peptide (distinct from the mature IGF-1 peptide) activates satellite cells — muscle stem cells that donate nuclei to growing or repairing muscle fibers. It upregu... |
| Half-Life | ~10-15 min (free); ~12-15 hours (bound to IGFBP-3/ALS complex) | Minutes (non-PEGylated); rapidly degraded by serum proteases |
| Bioavailability | ~100% (subcutaneous) | — |
| Molecular Weight | ~7649 g/mol | — |
| WADA Status | Prohibited | Prohibited |
| Research Half-Life | ~10-15 min (free); ~12-15 hours (bound to IGFBP-3/ALS complex) | Minutes (non-PEGylated); rapidly degraded by serum proteases |
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| Regulatory (US) | FDA-approved (Increlex, mecasermin) for severe primary IGF-1 deficiency. WADA-banned. | Not FDA-approved. Research chemical only. WADA-banned. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | IGF-1 | MGF |
|---|---|---|
| Purity Standard | ≥98% | ≥98% |
| CAS Number | N/A | N/A |
| Molecular Formula | N/A | N/A |
| Available Formats | 1mg | 2mg |
| Batch COAs Published | — | — |
| Stock Status | Out of stock | Out of stock |
Availability at Volta Peptides
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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