LL-37 in Canada
Antimicrobial / Immune
Also known as Cathelicidin, hCAP-18, CAMP.
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About LL-37
LL-37 is the only human cathelicidin antimicrobial peptide, a 37-amino-acid cationic peptide (sequence: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES) with broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, viruses, and biofilms. Beyond direct pathogen killing, LL-37 has immunomodulatory, wound-healing, and angiogenic properties. It is naturally produced by epithelial cells and immune cells as part of innate immunity, with vitamin D stimulating its endogenous production. A randomized controlled trial has evaluated topical LL-37 in venous leg ulcers.
Mechanism
LL-37 (C120H232N42O38) carries a net positive charge (+6) that binds negatively charged bacterial membranes, creating transmembrane pores causing cell lysis. It also has anti-biofilm activity. Immunomodulatory functions include both pro- and anti-inflammatory responses: it neutralizes endotoxins (LPS), recruits immune cells via chemotaxis, and triggers inflammasome signaling (P2X7 receptor). It interacts with host receptors FPRL-1, P2X7, and EGFR, boosting cell proliferation, angiogenesis, and immunoregulation. Topical LL-37 enhances keratinocyte and endothelial cell migration, re-epithelialization, and neovascularization.
In the meantime
Volta Peptides supplies materials strictly for in-vitro laboratory research. Nothing on this page is a drug, supplement, cosmetic or food, and nothing here is intended for human or animal use, clinical application or diagnostic procedures. The research summary above describes published literature and is not a claim of therapeutic benefit or a statement that this compound is offered for such use.