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Ipamorelin vs Sermorelin

Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.

Ipamorelin: DSermorelin: C
AttributeIpamorelinSermorelin
CategoryGrowth Hormone SecretagogueGrowth Hormone Secretagogue
Evidence RatingD — PreclinicalC — Phase I–II Clinical Trials
Clinical StatusResearch-only / Not approved for human usePreviously FDA-approved (Geref, discontinued); now used off-label via compounding
MechanismIpamorelin (sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2) selectively binds to the Growth Hormone Secretagogue Receptor (GHS-R1a) on anterior pituitary somatotroph cells, increasing cAMP and activating protein kinase A to promote pulsatile GH secretion. Its structural specificity means it fits only the GH...Sermorelin binds to GHRH receptors (GHRHR) on somatotroph cells in the anterior pituitary gland, stimulating both transcription of the HGH gene and pulsatile release of endogenous growth hormone. The released HGH increases protein synthesis, fat breakdown (lipolysis), and tissue repair across multip...
Half-Life~2 hours~10–20 minutes
BioavailabilityHigh SC bioavailability—
Molecular Weight~711.9 g/mol~3357.9 g/mol
WADA StatusProhibitedProhibited
Research Half-Life~2 hours~10–20 minutes
Key Use Cases
  • Anti-Aging
  • Body Composition
  • Sleep
  • Anti-Aging
  • Body Composition
  • Sleep
Safety Concerns
  • Widely regarded as the mildest GHS available; minimal side effects in published animal and human studies
  • Common: injection site reactions (redness, swelling, bruising) in 15-30% of users, resolving within 24-48 hours
  • Common: mild temporary "head rush" or flushing immediately after injection due to sudden vasodilation
  • Generally well-tolerated in clinical studies; safety data from published trials supports good tolerability profile
  • Common: injection site reactions (redness, swelling, mild pain — typically resolve within days)
  • Systemic: headaches, nausea, dizziness, facial flushing, drowsiness (mild, transient, usually in initial weeks as the body adjusts)
Contraindications
  • Active malignancy or personal/family history of cancer (GH promotes cell proliferation)
  • Pregnancy and breastfeeding
  • Pituitary disorders or prior pituitary surgery
  • Diabetes with retinopathy (GH can affect blood glucose and worsen retinopathy)
  • Active malignancy or active cancer (GH promotes cell proliferation)
  • Pregnancy and breastfeeding
  • Pituitary disorders or prior pituitary surgery
  • Uncontrolled diabetes, severe sleep apnea, or untreated hypertension
Regulatory (US)Not FDA-approved. Research chemical only. WADA-banned (S2 growth factor).Previously FDA-approved (Geref) for pediatric GH deficiency; voluntarily discontinued by manufacturer for commercial reasons. FDA confirmed in 2013 it was not withdrawn for safety. Available via compounding pharmacies. WADA-banned.

Research Material Specifications

Catalog specifications for the corresponding research materials, including batch documentation coverage.

SpecificationIpamorelinSermorelin
Purity Standard≥98%≥98%
CAS Number170851-70-486168-78-7
Molecular FormulaC₃₈H₄₉N₉O₅C₁₄₉H₂₄₆N₄₄O₄₂S
Available Formats10mg, 10mg5mg
Batch COAs Published2 on file1 on file
Stock StatusIn stockIn stock

Availability at Volta Peptides

Ipamorelin 10mg

≥98% purity · HPLC verified · In stock

$49

Sermorelin 5mg

≥98% purity · HPLC verified · In stock

$34

Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.

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