PT-141 vs Melanotan II
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
| Attribute | PT-141 | Melanotan II |
|---|---|---|
| Category | Sexual Health | Melanocortin Agonist |
| Evidence Rating | A — FDA Approved | F — No Regulatory Activity |
| Clinical Status | FDA-approved (Vyleesi for HSDD in premenopausal women) | Research-only / Not approved. Multiple regulatory warnings issued worldwide. |
| Mechanism | PT-141 (MW ~1025 g/mol, C50H68N14O10, half-life 2-6 hours) is a synthetic analog of alpha-MSH targeting MC3R and MC4R. MC4R activation in the CNS enhances dopamine release in the nucleus accumbens and medial preoptic area, increasing sexual motivation. Subcutaneous bioavailability is approximately 1... | MT-II activates melanocortin receptors MC1R through MC5R non-selectively. MC1R activation stimulates melanogenesis (skin tanning) in melanocytes. MC3R/MC4R activation in the CNS increases sexual arousal and desire via dopamine release pathways. MC4R activation centrally suppresses appetite. The non-... |
| Half-Life | ~2.5 hours | ~36 minutes IV; longer SC due to depot effect |
| Bioavailability | ~25% SC | — |
| Molecular Weight | ~1025.2 g/mol | ~1024.2 g/mol |
| WADA Status | Not Listed | Prohibited |
| Research Half-Life | ~2.5 hours | ~36 minutes IV; longer SC due to depot effect |
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| Regulatory (US) | FDA-approved (Vyleesi, 2019) for HSDD in premenopausal women. 1.75 mg SC on-demand, max 8 doses/month. | Not FDA-approved. FDA has issued warnings against use. Removed from Category 2 on April 15, 2026. PCAC review scheduled July 23-24, 2026 to determine compounding eligibility. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | PT-141 | Melanotan II |
|---|---|---|
| Purity Standard | — | ≥98% |
| CAS Number | — | 121062-08-6 |
| Molecular Formula | — | C₅₀H₆₉N₁₅O₉ |
| Available Formats | — | 10mg |
| Batch COAs Published | — | 1 on file |
| Stock Status | — | In stock |
Availability at Volta Peptides
PT-141
Not currently stocked at Volta Peptides.
Melanotan II 10mg
≥98% purity · HPLC verified · In stock
$34
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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