Melanotan II vs Bremelanotide
Research material comparison: purity standards, available formats, molecular data, batch COA documentation, and regulatory status. For in vitro research use only.
| Attribute | Melanotan II | Bremelanotide |
|---|---|---|
| Category | Melanocortin Agonist | Sexual Health |
| Evidence Rating | F — No Regulatory Activity | A — FDA Approved |
| Clinical Status | Research-only / Not approved. Multiple regulatory warnings issued worldwide. | FDA-approved (Vyleesi for premenopausal HSDD, June 2019) |
| Mechanism | MT-II activates melanocortin receptors MC1R through MC5R non-selectively. MC1R activation stimulates melanogenesis (skin tanning) in melanocytes. MC3R/MC4R activation in the CNS increases sexual arousal and desire via dopamine release pathways. MC4R activation centrally suppresses appetite. The non-... | Bremelanotide activates melanocortin 4 receptors (MC4R) and melanocortin 3 receptors (MC3R) in the central nervous system, particularly in hypothalamic nuclei involved in sexual arousal and desire. Unlike phosphodiesterase inhibitors that act on peripheral blood flow, bremelanotide acts centrally to... |
| Half-Life | ~36 minutes IV; longer SC due to depot effect | ~2.7 hours |
| Bioavailability | — | ~100% subcutaneous |
| Molecular Weight | ~1024.2 g/mol | ~1025.2 g/mol |
| WADA Status | Prohibited | Not Listed |
| Research Half-Life | ~36 minutes IV; longer SC due to depot effect | ~2.7 hours |
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| Regulatory (US) | Not FDA-approved. FDA has issued warnings against use. Removed from Category 2 on April 15, 2026. PCAC review scheduled July 23-24, 2026 to determine compounding eligibility. | FDA-approved (Vyleesi, June 2019) for premenopausal HSDD. Schedule not controlled. |
Research Material Specifications
Catalog specifications for the corresponding research materials, including batch documentation coverage.
| Specification | Melanotan II | Bremelanotide |
|---|---|---|
| Purity Standard | ≥98% | — |
| CAS Number | 121062-08-6 | — |
| Molecular Formula | C₅₀H₆₉N₁₅O₉ | — |
| Available Formats | 10mg | — |
| Batch COAs Published | 1 on file | — |
| Stock Status | In stock | — |
Availability at Volta Peptides
Melanotan II 10mg
≥98% purity · HPLC verified · In stock
$34
Bremelanotide
Not currently stocked at Volta Peptides.
Research Disclaimer: This comparison is provided for educational purposes only. All products are sold exclusively for in vitro research use. The information presented is based on published preclinical and clinical research and does not constitute medical advice. Consult a qualified healthcare professional before making any decisions regarding peptide use.
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