dna-encoded-libraries

DNA-Encoded Libraries Enable Tunable Cyclic Peptide Discovery

Researchers led by Petrov et al. in Nature Communications developed a dual-display ESAC library that provides three levels of conformational restraint in cyclic peptides: open, semi-closed, and fully closed. This 56 million-member library addresses purity and diversity issues in conventional DNA-encoded libraries. Selections against thrombin, streptavidin, and PLAP revealed target-specific preferences for peptide flexibility, guiding future designs.