Selank in Canada
Nootropic / Anxiolytic
Also known as TP-7, Selanc, Thr-Lys-Pro-Arg-Pro-Gly-Pro.
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About Selank
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, MW ~751.89 g/mol) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a structural analogue of the immunomodulatory peptide tuftsin with an added Pro-Gly-Pro sequence for stability. Approved in Russia as an anxiolytic and nootropic nasal spray, it crosses the blood-brain barrier to enhance GABAergic neurotransmission, modulate monoamine systems, and regulate neuropeptide Y signaling. A 2008 study of 62 patients with GAD showed Selank comparable to medazepam for anxiety reduction but with no sedation, cognitive impairment, or dependence risk. Half-life is approximately 2-10 minutes.
Mechanism
Selank (C33H57N11O9, half-life ~2-10 minutes) crosses the blood-brain barrier. It acts as a positive allosteric modulator of GABA-A receptors, increasing GABA binding affinity without directly activating the receptor (similar to benzodiazepines but without sedation or dependence). It enhances monoamine signaling (serotonin, noradrenaline), modulates neuropeptide Y for stress adaptation, protects enkephalins from enzymatic degradation (inhibiting enkephalinase), and has immunomodulatory properties through its tuftsin analogue structure. Gene expression studies show increased expression of specific GABA-A receptor subunits. Poor oral bioavailability but effective intranasally (bypasses first-pass metabolism, delivers directly to brain) or subcutaneously. Antiviral mechanism appears related to cytokine gene expression.
In the meantime
Volta Peptides supplies materials strictly for in-vitro laboratory research. Nothing on this page is a drug, supplement, cosmetic or food, and nothing here is intended for human or animal use, clinical application or diagnostic procedures. The research summary above describes published literature and is not a claim of therapeutic benefit or a statement that this compound is offered for such use.