therapeutic peptides
2 articles tagged with ‘therapeutic peptides’
HIV-Related Peptides: Mechanisms and Therapeutic Promise
Human immunodeficiency virus (HIV) leads to acquired immunodeficiency syndrome (AIDS) by weakening the immune system, allowing infections like those from Candida, Mycobacterium tuberculosis, and herpesviruses to thrive. Peptides offer high specificity in targeting HIV entry and life cycle stages, with advantages over small molecules. A key milestone came with the approval of the first peptide fusion inhibitor, and ongoing research addresses challenges like stability and cost.
Advanced Cyclic Peptide Synthesis in Drug Discovery
Natural cyclic peptides offer unique structures and potent biological effects, with over forty approved for clinical use in antibiotics, anticancer agents, immunomodulators, and anti-inflammatory drugs. Synthesis faces challenges from structural complexity and scalability needs. Recent studies since 2017 highlight evolving strategies like head-to-tail and side-chain linkages to improve efficiency.