cancer
2 articles tagged with ‘cancer’
Peptide Targeting: Solid Tumors vs Blood Cancers
Peptide designs for solid tumors focus on penetrating dense extracellular matrices and resisting harsh microenvironments, while those for hematological cancers prioritize rapid binding in circulation and evasion of clearance mechanisms. Accessibility defines the core challenge: solid tumors act as fortified structures with poor blood supply, unlike freely circulating blood cancer cells. These differences shape peptide length, stability features, and conjugation methods, with no universal approach suiting both.
Peptide Therapies Target Lung Injury, Cancer, Blood Disorders (Part 2)
This article covers research on synthetic amphipathic helical peptides that reduce inflammation in acute lung injury models, minihepcidins for treating β-thalassemia and polycythemia vera, stapled peptides blocking cancer metastasis via WASF3-CYFIP1, humanin derivatives protecting against necrosis in strokes and brain injuries, a FKBPL-mimicking peptide with FDA Orphan Drug Designation for ovarian cancer, and urotensin II's effects on multiple systems. Key studies from 2015-2016 highlight these peptides' potential. All findings preserve exact data from original research.