Why is HCG used with TRT?

Exogenous testosterone suppresses LH through negative feedback, causing testicular atrophy and infertility. HCG mimics LH, maintaining intratesticular testosterone production, testicular size, and spermatogenesis despite exogenous testosterone use.

HCG is a prescription medication that is FDA-approved for specific indications. It is legal with a prescription. It is banned by WADA in sports. The FDA also prohibits its marketing for weight loss.

What happened with HCG compounding?

In March 2020, the FDA reclassified HCG as a biologic under the BPCIA, removing it from the list of drugs that 503A pharmacies can compound. Only brand-name products or 503B outsourcing facilities can now provide it.

What is the recommended dose range for HCG?

The research dose range is 250-500 IU per injection (750-1500 IU/week), administered via Subcutaneous injection, 3 times per week.

peptide dosing

HCG Dosing & Reconstitution Guide

Complete dosing reference for HCG (Hormonal / Reproductive). Covers reconstitution, dose range, titration schedule, pharmacokinetics, and storage protocols for research use.

Dosing Protocol

Route: Subcutaneous injection Frequency: 3 times per week Dose Range: 250-500 IU per injection (750-1500 IU/week) Cycle Length: Ongoing while on TRT; or per fertility protocol Timing: Morning preferred; consistent timing

Reconstitution

Vial Size: 5000mg Water Volume: 2mL Concentration: 2500mg/mL

Titration Schedule

Weeks 1+: 500 IU three times per week (Mon/Wed/Fri)

Storage

Lyophilized: Refrigerate at 2-8 °C prior to reconstitution Reconstituted: Refrigerate, use within 30 days Shelf Life: 30 days

Injection Sites

Abdomen, Outer thigh

Safety & Contraindications

Safety: Common: injection site reactions, headache, fatigue, mood changes Males: gynecomastia (from estradiol conversion), water retention, testicular discomfort Females: ovarian hyperstimulation syndrome (OHSS) — potentially serious

Contraindications: Precocious puberty; Prostatic carcinoma or androgen-dependent neoplasm; Prior allergic reaction to HCG

Related Products

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HCG 5,000iu

5,000iu

Application formLyophilized powder

StorageRefrigerated

Purity98%

AppearanceLyophilized powder

$29 USD

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Research Use Only. The information on this page is compiled from published research literature and is provided for educational purposes only. It does not constitute medical advice. All compounds referenced are intended for in vitro research use by qualified laboratories and institutions.